An Immunohistochemical and Ultrastructural Study on Histogenesis and Differential Diagnosis with Clinicopatholological Analysis of Six Cases,” Virchows Archiv A, Pathological Anatomy and Histology, Vol. Ogawa, “Spindle Cell Squamous Carcinoma of the Oral Region. Chen, “Spindle Cell Carcinoma of the Oral Cavity and Oropharynx: Factors Affecting Outcome,” Journal of the Chinese Medical Association, Vol. Corio, “Spindle Cell Carcinoma of the Oral Cavity: A Clinicopathologic Assessment of Fifty Nine Cases,” Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Vol. Bouquot, “Oral and Maxillofacial Pathology: Saunders Elsivier,” 3rd Edition, Elsevier, Toronto, 2005, pp. Yamashita, “Spindle Cell Carcinoma of the Palatine Tonsil: Report of a Diagnostic Pitfall and Literature Review,” American Journal of Otolaryngology, Vol. Melato, “A Look at the Biology of Spindle Cell Squamous Carcinoma of the Oral Cavity: Report of a Case,” Journal of Oral and Maxillofacial Surgery, Vol. Ogura, “Spindle Cell Carcinoma (Pseudosarcoma) of the Larynx,” Archives of Otolaryngology, Vol. Because the lesion caused greater than a fifty-percent reduction in trachea luminal diameter, this patient experienced obstructive symptoms such as dyspnea and cough resulting in early detection prior to metastasis.
Heffner, “Spindle Cell (Sarcomatoid) Carcinomas of the Larynx: A Clinicopathologic Study of 187 Cases,” American Journal of Surgical Pathology, Vol. Spindle cell carcinoma or sarcomatoid carcinoma of the trachea is an uncommon tumor. Lee, “Sarcomatoid Carcinoma of the Parotid Gland with Apparent Metastasis of Epidermoid Elements to Cervical Lymph Nodes,” Acta Oto-Laryngologica, Vol. Kettle, “On Polymorphism of Malignant Epithelial Cell,” Proceedings of The Royal Society of Medicine, Vol. Thompson, “Squamous Cell Carcinoma Variants of the Head and Neck,” Current Diagnostic Pathology, Vol. Immunohistochemical analysis show concurrent presence of malignant epithelial and sarcomatoid spindle cell components by co-expression of cytokeratin (CK) and vimentin to various degrees. Biopsy specimens were subjected to histopathological examination followed by immunohistochemistry. In the surgery group recurrence rate was found to be 71.4% and metastasis rate was 21.4%. All the cases with disease of the larynx and hypopharynx were treated with radiotherapy and cases involving the nasopharynx received radiotherapy and chemotherapy. 14 cases of the oral cavity (buccal mucosa, alveolus, oral tongue and hard palate) were treated with surgery. Commonest site of presentation was nasopharynx and buccal mucosa. Out of total 40 cases included in the study group most of the cases were in the age group of 40 to 60 years. Borooah Cancer Institute, Guwahati, a regional institute for treatment and research, hereby report 40 cases of such lesion with clinicopathological and immunohistochemical study. Immunohistochemistry along with routine histopathology is essential in establishing the diagnosis of spindle cell carcinoma. It has a more aggressive behavior as compared to classical squomous cell carcinoma warranting surgical interventions with wider surgical margins.
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This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License (creativecommons.Spindle cell carcinoma of head and neck, a subtype of squamous cell carcinoma is a unique and rare neoplasm. Indian J Pathol Oncol 2018 5(3):512-515Ĭopyright © 2018 by author(s) and Indian J Pathol Oncol. u, Jayalakshmy P S, Sideeque A, Mucinous tubular and spindle cell carcinoma kidney with sarcomatoid and rhabdoid differentiation- A rare entity. Keywords: Mucinous tubular and spindle cell, Sarcomatoid, Rhabdoid. Sarcomatoid change is very rare in mucinous tubular and spindle cell tumor and we could find only 4 similar cases in the published literature. It is characterized by a large bulky mass in the middle third of the esophagus. We report a case of mucinous tubular and spindle cell neoplasm with areas having sarcomatoid and rhabdoid morphology with large areas of necrosis. Spindle-cell squamous carcinoma of the esophagus is a rare malignant tumor. Sarcomatoid change is described in many renal cell carcinomas, indicative of a worse clinical course. Mucinous tubular and spindle cell neoplasm is a rare renal tumor with favourable outcome. Background: Pulmonary spindle cell carcinoma is a type of variant sarcomatoid carcinoma, which is a very rare case. Mucinous tubular and spindle cell carcinoma kidney with sarcomatoid and rhabdoid differentiation- A rare entityĪuthor Details : Fadiya Zainudeen, Umasankar.
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